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ionizable lipid sm 102  (Croda International Plc)

 
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    Structured Review

    Croda International Plc ionizable lipid sm 102
    Ionizable Lipid Sm 102, supplied by Croda International Plc, used in various techniques. Bioz Stars score: 95/100, based on 48 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/ionizable lipid sm 102/product/Croda International Plc
    Average 95 stars, based on 48 article reviews
    ionizable lipid sm 102 - by Bioz Stars, 2026-05
    95/100 stars

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    Effect of buffer species of 50 mM acidic buffer used to <t>form</t> <t>SM-102</t> FLuc LNPs on liquid stability and bleb formation. (a) Percentage of bleb formation of LNPs obtained from cryo-TEM images. (b) Ratio of luminescence of HeLa cells transfected with LNPs before and after storage for 3 weeks at 25°C (%activity remaining). (c) Representative cryo-TEM images of LNPs before storage at 25°C. Scale bars represent 200 nm. Data are presented as mean ± SD (ANOVA with post-hoc Tukey’s multiple comparison test, n = 3). * P < 0.05.
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    Image Search Results


    Effect of buffer species of 50 mM acidic buffer used to form SM-102 FLuc LNPs on liquid stability and bleb formation. (a) Percentage of bleb formation of LNPs obtained from cryo-TEM images. (b) Ratio of luminescence of HeLa cells transfected with LNPs before and after storage for 3 weeks at 25°C (%activity remaining). (c) Representative cryo-TEM images of LNPs before storage at 25°C. Scale bars represent 200 nm. Data are presented as mean ± SD (ANOVA with post-hoc Tukey’s multiple comparison test, n = 3). * P < 0.05.

    Journal: bioRxiv

    Article Title: Bleb formation induced by acidic mixing buffers improves liquid stability of mRNA-LNPs

    doi: 10.64898/2026.03.05.709631

    Figure Lengend Snippet: Effect of buffer species of 50 mM acidic buffer used to form SM-102 FLuc LNPs on liquid stability and bleb formation. (a) Percentage of bleb formation of LNPs obtained from cryo-TEM images. (b) Ratio of luminescence of HeLa cells transfected with LNPs before and after storage for 3 weeks at 25°C (%activity remaining). (c) Representative cryo-TEM images of LNPs before storage at 25°C. Scale bars represent 200 nm. Data are presented as mean ± SD (ANOVA with post-hoc Tukey’s multiple comparison test, n = 3). * P < 0.05.

    Article Snippet: Specifically, we investigated the effect of less common acidic buffers on mRNA-LNP stability using a LNP containing a clinically relevant ionizable lipid (SM-102) that is used by Moderna as a part of their respiratory vaccine platform LNP.

    Techniques: Transfection, Activity Assay, Comparison

    Effect of apparent ionic strength of 50 mM pH 4 acidic mixing buffers on bleb formation of SM-102 LNPs.

    Journal: bioRxiv

    Article Title: Bleb formation induced by acidic mixing buffers improves liquid stability of mRNA-LNPs

    doi: 10.64898/2026.03.05.709631

    Figure Lengend Snippet: Effect of apparent ionic strength of 50 mM pH 4 acidic mixing buffers on bleb formation of SM-102 LNPs.

    Article Snippet: Specifically, we investigated the effect of less common acidic buffers on mRNA-LNP stability using a LNP containing a clinically relevant ionizable lipid (SM-102) that is used by Moderna as a part of their respiratory vaccine platform LNP.

    Techniques: